What is SPRAVATO®?
Treatment-resistant depression
- SPRAVATO® is the first FDA-approved nasal spray medication, taken with an oral antidepressant, for treatment-resistant depression in adults
- If you’ve tried two or more antidepressants* without sufficient relief, talk to your healthcare provider to see if you may have treatment-resistant depression *Of adequate dose and duration in your current episode.
- SPRAVATO® is not for use:
- As a medicine to prevent or relieve pain (anesthetic)
- To prevent suicide, reduce suicidal thoughts or actions, or replace hospitalization, even if there is improvement after the first dose
- SPRAVATO® is not for use in children
Things to discuss with your healthcare provider before taking SPRAVATO®
Do NOT take SPRAVATO® if any of the following applies to you:
- You have a blood vessel disease (aneurysm)
- You have an abnormal connection between your blood vessels (arteriovenous malformation)
- You have a history of bleeding in the brain
- You are allergic to esketamine or a similar medicine called ketamine used for anesthesia or any of the other ingredients in SPRAVATO®
Be sure to tell your healthcare provider if: - You have heart, brain or liver problems
- You have ever had psychosis (see, feel, or hear things that are not there, or believe in things that are not true)
- You are pregnant or breastfeeding. You should not take SPRAVATO® if you are pregnant or breastfeeding
- You are taking prescription or over-the-counter medicines, including vitamins or herbal supplements
Most common side effects:
- Dissociation
- Dizziness
- Nausea
- Feeling sleepy
- Spinning sensation
- Numbness
- Feeling anxious
- Lack of energy
- Increased blood pressure
- Vomiting
- Feeling drunk
- Feeling very happy or excited
If these common side effects occur, they usually happen right after taking SPRAVATO® and go away the same day.
These are not all the possible side effects of SPRAVATO®.
What should I know about the side effects of SPRAVATO®?
SPRAVATO® may cause serious side effects including:
- Feeling sleepy (sedation)
- Feeling disconnected from yourself, your thoughts, feelings and things around you (dissociation)
- Abuse and misuse
- Increased risk of suicidal thoughts and behavior
- Temporary increase in blood pressure that may last about four hours after a dose
- Problems with thinking clearly
- Bladder problems